The authors retrospectively reviewed the clinical records of 196 patients with dementia treated with memantine for at least 6 months. Eleven (5.6%) developed treatment-induced agitation. At chi-square analysis, they were significantly more likely to have a history of similar side effects from other medications acting on the central nervous system in comparison with the group without agitation, suggesting neurochemical susceptibility. A trend toward a significantly greater prevalence was also present for ischemic cardiopathy and neuroimaging evidence of chronic small vessel disease. Ischemic brain and heart disease might contribute through anatomical and functional alterations within the glutamatergic system.

DA RE, F., Rucci, F., Isella, V. (2015). Retrospective study on agitation provoked by memantine in dementia. THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 27(1), e10-e13 [10.1176/appi.neuropsych.13100226].

Retrospective study on agitation provoked by memantine in dementia

DA RE, FULVIO
Primo
;
ISELLA, VALERIA
Ultimo
2015

Abstract

The authors retrospectively reviewed the clinical records of 196 patients with dementia treated with memantine for at least 6 months. Eleven (5.6%) developed treatment-induced agitation. At chi-square analysis, they were significantly more likely to have a history of similar side effects from other medications acting on the central nervous system in comparison with the group without agitation, suggesting neurochemical susceptibility. A trend toward a significantly greater prevalence was also present for ischemic cardiopathy and neuroimaging evidence of chronic small vessel disease. Ischemic brain and heart disease might contribute through anatomical and functional alterations within the glutamatergic system.
Articolo in rivista - Articolo scientifico
memantine, dementia
English
2015
27
1
e10
e13
none
DA RE, F., Rucci, F., Isella, V. (2015). Retrospective study on agitation provoked by memantine in dementia. THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 27(1), e10-e13 [10.1176/appi.neuropsych.13100226].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/65813
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