We compared the levels of serum folate from Alzheimer’s disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91±2.44 and 7.56±2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2–4- fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor α

We compared the levels of serum folate from Alzheimer's disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91 +/- 2.44 and 7.56 +/- 2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2-4-fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor

Cazzaniga, E., Bulbarelli, A., Lonati, E., Re, F., Galimberti, G., Gatti, E., et al. (2008). Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients. NEUROSCIENCE LETTERS, 436(3), 317-320 [10.1016/j.neulet.2008.03.046].

Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients

CAZZANIGA, EMANUELA;BULBARELLI, ALESSANDRA;RE, FRANCESCA;PITTO, MARINA;FERRARESE, CARLO;MASSERINI, MASSIMO ERNESTO
2008

Abstract

We compared the levels of serum folate from Alzheimer’s disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91±2.44 and 7.56±2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2–4- fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor α
No
Articolo in rivista - Articolo scientifico
Scientifica
We compared the levels of serum folate from Alzheimer's disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91 +/- 2.44 and 7.56 +/- 2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2-4-fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor
Alzheimer’s disease, Folate, Fibroblasts, Folate carrier, Folate receptor α
Alzheimer's disease; Folate; Fibroblasts; Folate carrier; Folate receptor
English
317
320
4
Cazzaniga, E., Bulbarelli, A., Lonati, E., Re, F., Galimberti, G., Gatti, E., et al. (2008). Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients. NEUROSCIENCE LETTERS, 436(3), 317-320 [10.1016/j.neulet.2008.03.046].
Cazzaniga, E; Bulbarelli, A; Lonati, E; Re, F; Galimberti, G; Gatti, E; Pitto, M; Ferrarese, C; Masserini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/6577
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