Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
Maeda, T., Merghoub, T., Hobbs, R.M., Dong, L., Maeda, M., Zakrzewski, J., et al. (2007). Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. SCIENCE, 316(5826), 860-866 [10.1126/science.1140881].
Citazione: | Maeda, T., Merghoub, T., Hobbs, R.M., Dong, L., Maeda, M., Zakrzewski, J., et al. (2007). Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. SCIENCE, 316(5826), 860-866 [10.1126/science.1140881]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Titolo: | Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. | |
Autori: | Maeda, T; Merghoub, T; Hobbs, RM; Dong, L; Maeda, M; Zakrzewski, J; van den Brink, MR; Zelent, A; Shigematsu, H; Akashi, K; Teruya-Feldstein, J; Cattoretti, G; Pandolfi, PP | |
Autori: | ||
Data di pubblicazione: | 11-mag-2007 | |
Lingua: | English | |
Rivista: | SCIENCE | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1126/science.1140881 | |
Appare nelle tipologie: | 01 - Articolo su rivista |