Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

Maeda, T., Merghoub, T., Hobbs, R., Dong, L., Maeda, M., Zakrzewski, J., et al. (2007). Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. SCIENCE, 316(5826), 860-866 [10.1126/science.1140881].

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

CATTORETTI, GIORGIO;
2007-05-11

Abstract

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
Articolo in rivista - Articolo scientifico
;   Animals ;   BLymphocytes/*cytology/physiology ;   Bone Marrow Cells/cytology ;   Cell Lineage ;   Cells, Cultured ;   DNABinding Proteins/*genetics/physiology ;   Gene Deletion ;   Hematopoietic Stem Cells/*cytology/physiology ;   *Lymphopoiesis ;   Mice ;   Mice, Inbred C57BL ;   Mice, Knockout ;   Models, Biological ;   *ProtoOncogenes ;   Receptors, Notch/*metabolism ;   Signal Transduction ;   TLymphocytes/*cytology/physiology ;   Thymus Gland/cytology ;   Transcription Factors/*genetics/physiology
English
860
866
Maeda, T., Merghoub, T., Hobbs, R., Dong, L., Maeda, M., Zakrzewski, J., et al. (2007). Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. SCIENCE, 316(5826), 860-866 [10.1126/science.1140881].
Maeda, T; Merghoub, T; Hobbs, R; Dong, L; Maeda, M; Zakrzewski, J; van den Brink, M; Zelent, A; Shigematsu, H; Akashi, K; Teruya Feldstein, J; Cattoretti, G; Pandolfi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/6504
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