The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells. © 2014 American Chemical Society.
Avvakumova, S., Galbiati, E., Pandolfi, L., Mazzucchelli, S., Cassani, M., Gori, A., et al. (2014). Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells. BIOCONJUGATE CHEMISTRY, 25(8), 1381-1386 [10.1021/bc500202b].
Citazione: | Avvakumova, S., Galbiati, E., Pandolfi, L., Mazzucchelli, S., Cassani, M., Gori, A., et al. (2014). Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells. BIOCONJUGATE CHEMISTRY, 25(8), 1381-1386 [10.1021/bc500202b]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells | |
Autori: | Avvakumova, S; Galbiati, E; Pandolfi, L; Mazzucchelli, S; Cassani, M; Gori, A; Longhi, R; Prosperi, D | |
Autori: | ||
Data di pubblicazione: | 2014 | |
Lingua: | English | |
Rivista: | BIOCONJUGATE CHEMISTRY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/bc500202b | |
Appare nelle tipologie: | 01 - Articolo su rivista |