A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative. This journal is © the Partner Organisations 2014.
Avvakumova, S., Fezzardi, P., Pandolfi, L., Colombo, M., Sansone, F., Casnati, A., et al. (2014). Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells. CHEMICAL COMMUNICATIONS, 50(75), 11029-11032 [10.1039/c4cc03159h].
Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells
AVVAKUMOVA, SVETLANAPrimo
;PANDOLFI, LAURA;COLOMBO, MIRIAM;PROSPERI, DAVIDEUltimo
2014
Abstract
A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative. This journal is © the Partner Organisations 2014.
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