IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishObjectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management. © 2013 Anne Marie W. Efsen et al.
Efsen, A., Panteleev, A., Grint, D., Podlekareva, D., Vassilenko, A., Rakhmanova, A., et al. (2013). TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality. BIOMED RESEARCH INTERNATIONAL.
| Citazione: | Efsen, A., Panteleev, A., Grint, D., Podlekareva, D., Vassilenko, A., Rakhmanova, A., et al. (2013). TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality. BIOMED RESEARCH INTERNATIONAL. |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Carattere della pubblicazione: | Scientifica |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si |
| Titolo: | TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality |
| Autori: | Efsen, A; Panteleev, A; Grint, D; Podlekareva, D; Vassilenko, A; Rakhmanova, A; Zeltina, I; Losso, M; Miller, R; Girardi, E; Caylá, J; Post, F; Miro, J; Bruyand, M; Furrer, H; Obel, N; Lundgren, J; Mocroft, A; Kirk, O; Gori, A |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Lingua: | English |
| Rivista: | BIOMED RESEARCH INTERNATIONAL |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/2013/373601 |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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