This prospective study sought to identify the potential reversibility of oxaliplatin-induced peripheral neuropathy (OXAIPN) by following-up its long-term course 2 years after discontinuation of oxaliplatin (OXA)-based chemotherapy. Participants were 91 colorectal cancer patients treated with OXA-based chemotherapy. Neurological assessment, clinical Total Neuropathy Score© (TNSc©) and nerve conduction studies were performed at baseline (T0), the end of chemotherapy (T1) and 2 years (T2) after discontinuation of chemotherapy. A total of 73 of 91 (80%) patients experienced OXAIPN at T1. At a median follow-up of 25 months, persistence of chronic OXAIPN was present in 61 of 73 patients (84%) and complete resolution was present in 12 patients (17%). Longitudinal comparison of TNSc© values between T1 and T2 revealed that the overall severity of OXAIPN in those 61 patients significantly decreased over time. Median TNSc© values were nine (range: 2-15) at T1 vs. four (range: 2-12) at T2 (P < 0.001). Likewise, sensory nerve conduction measures at T2 significantly improved in all sensory nerves tested, compared with T1. Severity of OXAIPN at T2 was significantly associated (P < 0.001) with high severity of OXAIPN at T1. In conclusion, persistence of OXAIPN beyond 2 years after finishing chemotherapy is common. Clinical and neurophysiological improvement is observed, although recovery is often incomplete.
Briani, C., Argyriou, A., Izquierdo, C., Velasco, R., Campagnolo, M., Alberti, P., et al. (2014). Long-term course of oxaliplatin-induced polyneuropathy: a prospective two-year follow-up study. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 19(4), 299-306 [10.1111/jns.12097].
|Citazione:||Briani, C., Argyriou, A., Izquierdo, C., Velasco, R., Campagnolo, M., Alberti, P., et al. (2014). Long-term course of oxaliplatin-induced polyneuropathy: a prospective two-year follow-up study. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 19(4), 299-306 [10.1111/jns.12097].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Long-term course of oxaliplatin-induced polyneuropathy: a prospective two-year follow-up study|
|Autori:||Briani, C; Argyriou, A; Izquierdo, C; Velasco, R; Campagnolo, M; Alberti, P; Frigeni, B; Cacciavillani, M; Bergamo, F; Cortinovis, D; Cazzaniga, M; Bruna, J; Cavaletti, G; Kalofonos, H|
|Data di pubblicazione:||2014|
|Rivista:||JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/jns.12097|
|Appare nelle tipologie:||01 - Articolo su rivista|