Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
Piazza, F., Boncoraglio, G., Savoiardo, M., Farina, L., DiFrancesco, J., Prioni, S., et al. (2015). Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. JOURNAL OF ALZHEIMER'S DISEASE, 45(2), 363-367.
Citazione: | Piazza, F., Boncoraglio, G., Savoiardo, M., Farina, L., DiFrancesco, J., Prioni, S., et al. (2015). Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. JOURNAL OF ALZHEIMER'S DISEASE, 45(2), 363-367. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies |
Autori: | Piazza, F; Boncoraglio, G; Savoiardo, M; Farina, L; DiFrancesco, J; Prioni, S; Tagliavini, F; Parati, E; Giaccone, G |
Autori: | PIAZZA, FABRIZIO (Primo) |
Data di pubblicazione: | 2015 |
Lingua: | English |
Rivista: | JOURNAL OF ALZHEIMER'S DISEASE |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3233/JAD-142376 |
Appare nelle tipologie: | 01 - Articolo su rivista |