Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.

Piazza, F., Boncoraglio, G., Savoiardo, M., Farina, L., DI FRANCESCO, J., Prioni, S., et al. (2015). Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. JOURNAL OF ALZHEIMER'S DISEASE, 45(2), 363-367 [10.3233/JAD-142376].

Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies

PIAZZA, FABRIZIO
Primo
;
Boncoraglio, G
;
DI FRANCESCO, JACOPO COSIMO;
2015

Abstract

Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
Articolo in rivista - Articolo scientifico
Alzheimer's disease; amyloid-related imaging abnormalities; anti-Aβ autoantibodies; cerebral amyloid angiopathy; cerebral amyloid angiopathy-related inflammation; subarachnoid hemorrhage;
English
2015
45
2
363
367
reserved
Piazza, F., Boncoraglio, G., Savoiardo, M., Farina, L., DI FRANCESCO, J., Prioni, S., et al. (2015). Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. JOURNAL OF ALZHEIMER'S DISEASE, 45(2), 363-367 [10.3233/JAD-142376].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/61983
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