The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell-conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1-inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.

Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G., et al. (2005). Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. NATURE IMMUNOLOGY, 2005, 507-514 [10.1038/ni1192].

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

NESPOLI, ANGELO;
2005

Abstract

The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell-conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1-inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.
Articolo in rivista - Articolo scientifico
Scientifica
THYMIC STROMAL LYMPHOPOIETIN; ALLERGIC INFLAMMATION; BACTERIAL CLEARANCE; COMMENSAL BACTERIA; TOXOPLASMA-GONDII; T-CELLS; B-CELLS; RESPONSES; INFECTION;
English
507
514
Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G., et al. (2005). Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. NATURE IMMUNOLOGY, 2005, 507-514 [10.1038/ni1192].
Rimoldi, M; Chieppa, M; Salucci, V; Avogadri, F; Sonzogni, A; Sampietro, G; Nespoli, A; Viale, G; Allavena, P; Rescigno, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/6090
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