The aim of this paper is to report the data concerning the contamination of the exhausted air from the hot cells dedicated to the large-scale synthesis of positron emission tomography (PET) radiopharmaceuticals. Two cyclotrons are currently operating in Ospedale San Raffaele for the routine production of C and F. They are linked with four radiochemistry laboratories by means of shielded radioisotope delivery lines. The above labs are dedicated both to the large scale preparation and to the research and development of PET radiopharmaceuticals. The department hosts four CT-PET scanners, which operate with a mean patient workload of 40 per day. Radiosyntheses are performed using automated modules located in 10 hot cells. The air outlets are monitored online by a 2-inch NaI(Tl) counter in a Marinelli geometry counting volume. Contamination values up to 10(5) Bq L(-1) have been measured at the hot cell exit point during the synthesis. The corresponding concentrations at the point of release in atmosphere are largely above the threshold of 1.29 Bq L(-1), defined by national regulations as the limit for free environmental release. A shielded gas storage system controlled by a dedicated, customized software program has thus been installed to prevent the potentially hazardous release of gaseous radioactive contaminants. The system has allowed us to maintain the effective dose to neighboring population groups below the limit of 10 muSv y(-1)

Calandrino, R., del Vecchio, A., Todde, S., & Fazio, F. (2007). Measurement and control of the air contamination generated in a medical cyclotron facility for PET radiopharmaceuticals. HEALTH PHYSICS, 92(5 suppl.), S70-S77.

Measurement and control of the air contamination generated in a medical cyclotron facility for PET radiopharmaceuticals

TODDE, SERGIO CAMILLO;FAZIO, FERRUCCIO
2007

Abstract

The aim of this paper is to report the data concerning the contamination of the exhausted air from the hot cells dedicated to the large-scale synthesis of positron emission tomography (PET) radiopharmaceuticals. Two cyclotrons are currently operating in Ospedale San Raffaele for the routine production of C and F. They are linked with four radiochemistry laboratories by means of shielded radioisotope delivery lines. The above labs are dedicated both to the large scale preparation and to the research and development of PET radiopharmaceuticals. The department hosts four CT-PET scanners, which operate with a mean patient workload of 40 per day. Radiosyntheses are performed using automated modules located in 10 hot cells. The air outlets are monitored online by a 2-inch NaI(Tl) counter in a Marinelli geometry counting volume. Contamination values up to 10(5) Bq L(-1) have been measured at the hot cell exit point during the synthesis. The corresponding concentrations at the point of release in atmosphere are largely above the threshold of 1.29 Bq L(-1), defined by national regulations as the limit for free environmental release. A shielded gas storage system controlled by a dedicated, customized software program has thus been installed to prevent the potentially hazardous release of gaseous radioactive contaminants. The system has allowed us to maintain the effective dose to neighboring population groups below the limit of 10 muSv y(-1)
Articolo in rivista - Articolo scientifico
Scientifica
PET, radiopharmaceuticals, air contamination
English
S70
S77
Calandrino, R., del Vecchio, A., Todde, S., & Fazio, F. (2007). Measurement and control of the air contamination generated in a medical cyclotron facility for PET radiopharmaceuticals. HEALTH PHYSICS, 92(5 suppl.), S70-S77.
Calandrino, R; del Vecchio, A; Todde, S; Fazio, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/6080
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