A previous study reporting on 44 patients who underwent awake surgery for a left frontal or temporal glioma resection demonstrated the removal of the uncinate fasciculus to have consequences on language 3 months post-surgery. At this time-point, patients with a temporal glioma who had undergone uncinate removal showed the worst overall performance with a significant impairment in naming of famous faces and objects compared to patients without removal. Also, verbal fluency was mildly impaired. We report a longer-term follow-up (9–12 months) in a selected group of 17 patients (six female, age range 27–64) who did not suffer any tumour recurrence in this timeframe. MRI and DTI were performed before and after surgery. While verbal fluency on categorical cue and object naming recovered to the same level as before surgery, proper naming remained significantly impaired even after 12 months (P = 0.032) in patients with uncinate removal, demonstrating this structure to be crucial for that function and supporting the hypothesis that subcortical connectivity is relevant to allow plasticity. We thus argued that the left frontal and temporal poles connected by means of the uncinate fasciculus constitute a dedicated circuit for naming of unique entities.

Papagno, C., Casarotti, A., Comi, A., Pisoni, A., Lucchelli, F., Bizzi, A., et al. (2016). Long-term proper name anomia after removal of the uncinate fasciculus. BRAIN STRUCTURE AND FUNCTION, 221(1), 687-694 [10.1007/s00429-014-0920-8].

Long-term proper name anomia after removal of the uncinate fasciculus

PAPAGNO, COSTANZA
;
CASAROTTI, ALESSANDRA;COMI, ALESSANDRO;PISONI, ALBERTO;
2016

Abstract

A previous study reporting on 44 patients who underwent awake surgery for a left frontal or temporal glioma resection demonstrated the removal of the uncinate fasciculus to have consequences on language 3 months post-surgery. At this time-point, patients with a temporal glioma who had undergone uncinate removal showed the worst overall performance with a significant impairment in naming of famous faces and objects compared to patients without removal. Also, verbal fluency was mildly impaired. We report a longer-term follow-up (9–12 months) in a selected group of 17 patients (six female, age range 27–64) who did not suffer any tumour recurrence in this timeframe. MRI and DTI were performed before and after surgery. While verbal fluency on categorical cue and object naming recovered to the same level as before surgery, proper naming remained significantly impaired even after 12 months (P = 0.032) in patients with uncinate removal, demonstrating this structure to be crucial for that function and supporting the hypothesis that subcortical connectivity is relevant to allow plasticity. We thus argued that the left frontal and temporal poles connected by means of the uncinate fasciculus constitute a dedicated circuit for naming of unique entities.
Articolo in rivista - Articolo scientifico
Anterior temporal lobe; Glioma; Proper names; Uncinate fasciculus;
Anterior temporal lobe; Glioma; Proper names; Uncinate fasciculus
English
687
694
8
Papagno, C., Casarotti, A., Comi, A., Pisoni, A., Lucchelli, F., Bizzi, A., et al. (2016). Long-term proper name anomia after removal of the uncinate fasciculus. BRAIN STRUCTURE AND FUNCTION, 221(1), 687-694 [10.1007/s00429-014-0920-8].
Papagno, C; Casarotti, A; Comi, A; Pisoni, A; Lucchelli, F; Bizzi, A; Riva, M; Bello, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/60528
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