Experimental Autoimmune Encephalomyelitis (EAE) is a good model of Multiple Sclerosis in rodents. We have applied fMRI to invesigate the alteration in functional response in rats induced with EAE. Cortical activation is altered in EAE rat brain, compared to controls. fMRI showed an increase in the activated volume involving also the cortex ipsilateral and some extra-cortical areas at the observed time points. These results demonstrate brain cortex remodeling in EAE, a remakable feature of MS. The present model seems to be a relevant tool in preclinical MS studies.
Tambalo, S., Fiorini, S., Rigolio, R., Bontempi, P., Sbarbati, A., Cavaletti, G., et al. (2014). Functional Magnetic Resonance Imaging Reveals Brain Cortex Remodeling in a Rat Model of Chronic Multiple Sclerosis. In Abstract Book.
Functional Magnetic Resonance Imaging Reveals Brain Cortex Remodeling in a Rat Model of Chronic Multiple Sclerosis
RIGOLIO, ROBERTA;CAVALETTI, GUIDO ANGELO;MARMIROLI, PAOLA LORENA;
2014
Abstract
Experimental Autoimmune Encephalomyelitis (EAE) is a good model of Multiple Sclerosis in rodents. We have applied fMRI to invesigate the alteration in functional response in rats induced with EAE. Cortical activation is altered in EAE rat brain, compared to controls. fMRI showed an increase in the activated volume involving also the cortex ipsilateral and some extra-cortical areas at the observed time points. These results demonstrate brain cortex remodeling in EAE, a remakable feature of MS. The present model seems to be a relevant tool in preclinical MS studies.
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