Immature teratoma of the ovary is a rare condition primarily affecting young women and constitutes a significant proportion of ovarian cancer cases in adolescents and young adults. It is commonly diagnosed at stage I, though advanced-stage disease is not infrequent. Accurate diagnosis and a fertility-sparing approach are central to the management of this condition, as many affected women retain, or have yet to develop, a desire for childbearing. However, due to the rarity of this disease, management is often guided by retrospective data derived from subanalyses of studies on malignant ovarian germ cell tumors, which can complicate the treatment of these patients once diagnosed. The aim of this review is to summarize the current evidence on immature teratoma of the ovary, considering it as a distinct clinical and pathological entity.

Marino, G., Negri, S., Testa, F., Corti, J., Giuliani, D., Lugotti, D., et al. (2025). Immature Teratoma of the Ovary—A Narrative Review. CANCERS, 17(18) [10.3390/cancers17183041].

Immature Teratoma of the Ovary—A Narrative Review

Marino G.
Primo
;
Negri S.;Testa F.;Corti J.;Giuliani D.;Lugotti D.;Grassi T.;Casiraghi A.;Fruscio R.
Ultimo
2025

Abstract

Immature teratoma of the ovary is a rare condition primarily affecting young women and constitutes a significant proportion of ovarian cancer cases in adolescents and young adults. It is commonly diagnosed at stage I, though advanced-stage disease is not infrequent. Accurate diagnosis and a fertility-sparing approach are central to the management of this condition, as many affected women retain, or have yet to develop, a desire for childbearing. However, due to the rarity of this disease, management is often guided by retrospective data derived from subanalyses of studies on malignant ovarian germ cell tumors, which can complicate the treatment of these patients once diagnosed. The aim of this review is to summarize the current evidence on immature teratoma of the ovary, considering it as a distinct clinical and pathological entity.
Articolo in rivista - Review Essay
controversies; fertility-sparing; immature teratomas; malignant ovarian germ cell tumors; management; ovarian cancer;
English
18-set-2025
2025
17
18
3041
open
Marino, G., Negri, S., Testa, F., Corti, J., Giuliani, D., Lugotti, D., et al. (2025). Immature Teratoma of the Ovary—A Narrative Review. CANCERS, 17(18) [10.3390/cancers17183041].
File in questo prodotto:
File Dimensione Formato  
Marino et al-2025-Cancers-VoR.pdf

accesso aperto

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 335.4 kB
Formato Adobe PDF
335.4 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/600084
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
Social impact