Data from animals and from man suggest that calcium antagonists interfere with aadrenergic receptors and that this mechanism may be responsible for some of the vasodilation induced by these drugs. However, a-adrenergic receptors play a primary role in baroreceptor regulation of the cardiovascular system and blood pressure homeostasis, which might therefore be adversely affected by calcium antagonist treatment. We addressed this question in 14 essential hypertensives studied before treatment, 1 h after 20 mg oral nitrendipine and 5-7 days after daily administration of 20 mg oral nitrendipine. Blood pressure was measured by an intra-arterial catheter, heart rate by an electrocardiogram, cardiac output by thermodilution and forearm blood flow by venous occlusion plethysmography. Total peripheral and forearm vascular resistances were calculated by dividing mean blood pressure by blood flow values. Plasma norepinephrine was also measured (high performance liquid chromatography) in blood tak...

Mancia, G., Parati, G., Grassi, G., Pomidossi, G., Giannattasio, C., Casadei, R., et al. (1987). Calcium antagonists and neural control of circulation in essential hypertension. JOURNAL OF HYPERTENSION, 5(4), S49-S55 [10.1097/00004872-198712004-00009].

Calcium antagonists and neural control of circulation in essential hypertension

MANCIA, GIUSEPPE
Primo
;
PARATI, GIANFRANCO
Secondo
;
GRASSI, GUIDO;GIANNATTASIO, CRISTINA;SAINO, ANTONIO TOMMASO;
1987

Abstract

Data from animals and from man suggest that calcium antagonists interfere with aadrenergic receptors and that this mechanism may be responsible for some of the vasodilation induced by these drugs. However, a-adrenergic receptors play a primary role in baroreceptor regulation of the cardiovascular system and blood pressure homeostasis, which might therefore be adversely affected by calcium antagonist treatment. We addressed this question in 14 essential hypertensives studied before treatment, 1 h after 20 mg oral nitrendipine and 5-7 days after daily administration of 20 mg oral nitrendipine. Blood pressure was measured by an intra-arterial catheter, heart rate by an electrocardiogram, cardiac output by thermodilution and forearm blood flow by venous occlusion plethysmography. Total peripheral and forearm vascular resistances were calculated by dividing mean blood pressure by blood flow values. Plasma norepinephrine was also measured (high performance liquid chromatography) in blood tak...
Articolo in rivista - Articolo scientifico
Baroreflexes; Blood pressure; Cardiac output; Cardiopulmonary reflexes; Exercise; Hypertension; Nitrendipine; Peripheral circulation;
Adult; Blood Circulation; Blood Pressure; Calcium Channel Blockers; Carotid Sinus; Dose-Response Relationship, Drug; Drug Evaluation; Hemodynamics; Humans; Hypertension; Middle Aged; Nitrendipine; Reflex
English
1987
5
4
S49
S55
none
Mancia, G., Parati, G., Grassi, G., Pomidossi, G., Giannattasio, C., Casadei, R., et al. (1987). Calcium antagonists and neural control of circulation in essential hypertension. JOURNAL OF HYPERTENSION, 5(4), S49-S55 [10.1097/00004872-198712004-00009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59793
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