Studies performed in both animal and human species have shown that receptors anatomically located in the cardiac walls and in the pulmonary vascular bed exert a powerful influence on sympathetic vasoconstrictor tone and renin release from the kidney. This paper will review recent data collected by our group on the effects on this homeostatic reflex function of two different models of cardiac hypertrophy, i.e. that associated with arterial hypertension and that induced by prolonged physical training. It will also examine whether and to what extent cardiopulmonary reflex control of circulation can be restored after an effective antihypertensive pharmacological treatment has induced a regression of the structural alterations of the heart. The results of these studies suggest that cardiopulmonary reflex control of circulation is markedly impaired in the presence of cardiac hypertrophy, with (severe hypertensive subjects) or without (athletes) high blood pressure values. In hypertensives, furthermore, therapeutic regression of cardiac hypertrophy seems to restore, although not fully normalize, this reflex function. Taken together these findings suggest that cardiac hypertrophy, per se, is a condition characterized by the loss of the reflex functions exerted by cardiac receptors, with adverse consequences on cardiovascular homeostasis.

Grassi, G., Giannattasio, C., Seravalle, G., Cattaneo, B., Cléroux, J., Mancia, G. (1990). Cardiogenic reflexes and left ventricular hypertrophy. EUROPEAN HEART JOURNAL, 11, 95-99 [10.1093/eurheartj/11.suppl_g.95].

Cardiogenic reflexes and left ventricular hypertrophy

GRASSI, GUIDO
Primo
;
GIANNATTASIO, CRISTINA
Secondo
;
MANCIA, GIUSEPPE
Ultimo
1990

Abstract

Studies performed in both animal and human species have shown that receptors anatomically located in the cardiac walls and in the pulmonary vascular bed exert a powerful influence on sympathetic vasoconstrictor tone and renin release from the kidney. This paper will review recent data collected by our group on the effects on this homeostatic reflex function of two different models of cardiac hypertrophy, i.e. that associated with arterial hypertension and that induced by prolonged physical training. It will also examine whether and to what extent cardiopulmonary reflex control of circulation can be restored after an effective antihypertensive pharmacological treatment has induced a regression of the structural alterations of the heart. The results of these studies suggest that cardiopulmonary reflex control of circulation is markedly impaired in the presence of cardiac hypertrophy, with (severe hypertensive subjects) or without (athletes) high blood pressure values. In hypertensives, furthermore, therapeutic regression of cardiac hypertrophy seems to restore, although not fully normalize, this reflex function. Taken together these findings suggest that cardiac hypertrophy, per se, is a condition characterized by the loss of the reflex functions exerted by cardiac receptors, with adverse consequences on cardiovascular homeostasis.
Articolo in rivista - Articolo scientifico
Adult; Cardiomegaly; Exercise Therapy; Heart; Homeostasis; Humans; Hypertension; Pressoreceptors; Reflex
English
1990
11
95
99
none
Grassi, G., Giannattasio, C., Seravalle, G., Cattaneo, B., Cléroux, J., Mancia, G. (1990). Cardiogenic reflexes and left ventricular hypertrophy. EUROPEAN HEART JOURNAL, 11, 95-99 [10.1093/eurheartj/11.suppl_g.95].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59755
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