This article reviews evidence that the reflex control of the cardiovascular system provided by negative feedback mechanisms is impaired in congestive heart failure (CHF). The impairment involves vagal and sympathetic modulation of the heart exerted by arterial baroreceptors. It also affects baroreceptor control of blood pressure and peripheral vascular resistance, as well as the cardiopulmonary receptor's ability to modulate sympathetic activity. The degree of such impairment is most marked in severe CHF but is also apparent, to a minor degree, in mild heart failure. Reflex impairment is due to a reduction in the receptor signal, but other factor under investigation are probably also involved. Digoxin and other pharmacologic treatments of CHF improve reflex function, thereby facilitating a reduction in the elevated sympathetic activity and a stepping up of the reduced vagal activity typical of CHF. This may be relevant to a patient's prognosis.

Mancia, G., Seravalle, G., Giannattasio, C., Bossi, M., Preti, L., Cattaneo, B., et al. (1992). Reflex cardiovascular control in congestive heart failure. THE AMERICAN JOURNAL OF CARDIOLOGY, 69(18), 17G-22G.

Reflex cardiovascular control in congestive heart failure

MANCIA, GIUSEPPE
Primo
;
GIANNATTASIO, CRISTINA;BOSSI, MARIO;GRASSI, GUIDO
Ultimo
1992

Abstract

This article reviews evidence that the reflex control of the cardiovascular system provided by negative feedback mechanisms is impaired in congestive heart failure (CHF). The impairment involves vagal and sympathetic modulation of the heart exerted by arterial baroreceptors. It also affects baroreceptor control of blood pressure and peripheral vascular resistance, as well as the cardiopulmonary receptor's ability to modulate sympathetic activity. The degree of such impairment is most marked in severe CHF but is also apparent, to a minor degree, in mild heart failure. Reflex impairment is due to a reduction in the receptor signal, but other factor under investigation are probably also involved. Digoxin and other pharmacologic treatments of CHF improve reflex function, thereby facilitating a reduction in the elevated sympathetic activity and a stepping up of the reduced vagal activity typical of CHF. This may be relevant to a patient's prognosis.
Articolo in rivista - Articolo scientifico
Animals; Blood Circulation; Blood Volume; Heart; Heart Failure; Heart Rate; Humans; Lung; Pressoreceptors; Reflex
English
17G
22G
Mancia, G., Seravalle, G., Giannattasio, C., Bossi, M., Preti, L., Cattaneo, B., et al. (1992). Reflex cardiovascular control in congestive heart failure. THE AMERICAN JOURNAL OF CARDIOLOGY, 69(18), 17G-22G.
Mancia, G; Seravalle, G; Giannattasio, C; Bossi, M; Preti, L; Cattaneo, B; Grassi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59733
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