Mitochondria are semi-autonomously reproductive organelles within eukaryotic cells carrying their own genetic material, called the mitochondrial genome (mtDNA). Until some years ago, mtDNA had primarily been used as a tool in population genetics. As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health. Today, mitochondria research covers a wide range of disciplines, including clinical medicine, biochemistry, genetics, molecular cell biology, bioinformatics, plant sciences and physiology. The present review intends to present a summary of the most exiting fi elds of the mitochondrial research bringing together several contributes in terms of original prospective and future applications.

Crimi, M., Rigolio, R. (2008). The mitochondrial genome, a growing interest inside an organelle. INTERNATIONAL JOURNAL OF NANOMEDICINE, 3(1), 51-57 [10.2147/IJN.S2482].

The mitochondrial genome, a growing interest inside an organelle

RIGOLIO, ROBERTA
Ultimo
2008

Abstract

Mitochondria are semi-autonomously reproductive organelles within eukaryotic cells carrying their own genetic material, called the mitochondrial genome (mtDNA). Until some years ago, mtDNA had primarily been used as a tool in population genetics. As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health. Today, mitochondria research covers a wide range of disciplines, including clinical medicine, biochemistry, genetics, molecular cell biology, bioinformatics, plant sciences and physiology. The present review intends to present a summary of the most exiting fi elds of the mitochondrial research bringing together several contributes in terms of original prospective and future applications.
Articolo in rivista - Articolo scientifico
mtDNA, heteroplasmy, molecular diagnostics, mitochondriopathies, nanogenomics
English
2008
3
1
51
57
open
Crimi, M., Rigolio, R. (2008). The mitochondrial genome, a growing interest inside an organelle. INTERNATIONAL JOURNAL OF NANOMEDICINE, 3(1), 51-57 [10.2147/IJN.S2482].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59191
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