Glutamate has been implicated in the pathogenesis of several diseases on the central nervous system, but recent studies have also suggested that it can be involved also in the onset and course of peripheral neuropathies. Given the increasing evidence of this possibility, several attempts have been performed in order to modulate its activity. Among them, glutamate carboxypeptidase II (GCP II) inhibition demonstrated promising results in different models of peripheral nerve damage, including diabetic and toxic neuropathies

Carozzi, V., Ceresa, C. (2012). The role of glutamate in diabetic and in chemotherapy induced peripheral neuropathies and its regulation by glutamate carboxypeptidase II. CURRENT MEDICINAL CHEMISTRY, 19(9), 1261-1268 [10.2174/092986712799462694].

The role of glutamate in diabetic and in chemotherapy induced peripheral neuropathies and its regulation by glutamate carboxypeptidase II.

CAROZZI, VALENTINA ALDA
Primo
;
CERESA, CECILIA
Ultimo
2012

Abstract

Glutamate has been implicated in the pathogenesis of several diseases on the central nervous system, but recent studies have also suggested that it can be involved also in the onset and course of peripheral neuropathies. Given the increasing evidence of this possibility, several attempts have been performed in order to modulate its activity. Among them, glutamate carboxypeptidase II (GCP II) inhibition demonstrated promising results in different models of peripheral nerve damage, including diabetic and toxic neuropathies
Articolo in rivista - Review Essay
glutamate, peripheral neuropathy
English
2012
19
9
1261
1268
reserved
Carozzi, V., Ceresa, C. (2012). The role of glutamate in diabetic and in chemotherapy induced peripheral neuropathies and its regulation by glutamate carboxypeptidase II. CURRENT MEDICINAL CHEMISTRY, 19(9), 1261-1268 [10.2174/092986712799462694].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59140
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