Cisplatin, paclitaxel and bortezomib are effective chemotherapy drugs in cancer treatment. However, they share severe peripheral neurotoxicity (PN) as one of their major dose-limiting side effects, often impairing cancer patients' quality of life and sometimes being permanent. Even if preclinical oncology is largely based on the use of immune-deficient mice, rodent models used to study the chemotherapy-induced PN are available only in immune-competent animals. In this study we characterized for the first time the PN induced by these chemotherapies through neurophysiological, behavioral, morphological and morphometric studies in athymic nude mice, a commonly employed strain in the preclinical oncology. The animals, divided into four groups, were chronically treated with cisplatin, paclitaxel or bortezomib once or twice a week for 4 or 6. weeks or were left untreated. These schedules were tolerated, neurotoxic and in the range of antineoplastic effectiveness. Despite similarities, differences in the features of PN were evident if compared with immune-competent models under comparable regimens of treatment. The results of this study may provide a basis for future combined analysis of antineoplastic and neurotoxic effects of chemotherapy in the same animals.

Carozzi, V., Chiorazzi, A., Canta, A., Meregalli, C., Oggioni, N., Cavaletti, G., et al. (2015). Chemotherapy-induced peripheral neurotoxicity in immune-deficient mice: New useful ready-to-use animal models. EXPERIMENTAL NEUROLOGY, 264, 92-102 [10.1016/j.expneurol.2014.11.002].

Chemotherapy-induced peripheral neurotoxicity in immune-deficient mice: New useful ready-to-use animal models

CAROZZI, VALENTINA ALDA
Primo
;
CHIORAZZI, ALESSIA
Secondo
;
CANTA, ANNALISA ROSANNA;MEREGALLI, CRISTINA;OGGIONI, NORBERTO;CAVALETTI, GUIDO ANGELO
Penultimo
;
MARMIROLI, PAOLA LORENA
Ultimo
2015

Abstract

Cisplatin, paclitaxel and bortezomib are effective chemotherapy drugs in cancer treatment. However, they share severe peripheral neurotoxicity (PN) as one of their major dose-limiting side effects, often impairing cancer patients' quality of life and sometimes being permanent. Even if preclinical oncology is largely based on the use of immune-deficient mice, rodent models used to study the chemotherapy-induced PN are available only in immune-competent animals. In this study we characterized for the first time the PN induced by these chemotherapies through neurophysiological, behavioral, morphological and morphometric studies in athymic nude mice, a commonly employed strain in the preclinical oncology. The animals, divided into four groups, were chronically treated with cisplatin, paclitaxel or bortezomib once or twice a week for 4 or 6. weeks or were left untreated. These schedules were tolerated, neurotoxic and in the range of antineoplastic effectiveness. Despite similarities, differences in the features of PN were evident if compared with immune-competent models under comparable regimens of treatment. The results of this study may provide a basis for future combined analysis of antineoplastic and neurotoxic effects of chemotherapy in the same animals.
Articolo in rivista - Articolo scientifico
Athymic mice; Bortezomib; Cisplatin; Paclitaxel; Painful peripheral neuropathy; Analysis of Variance; Animals; Antineoplastic Agents; Body Weight; Disease Models, Animal; Female; Forkhead Transcription Factors; Ganglia, Spinal; Hyperalgesia; Mice; Mice, Nude; Neural Conduction; Neurotoxicity Syndromes; Nociception; Peripheral Nervous System Diseases; Sciatic Nerve; Sensory Thresholds; Time Factors
English
2015
264
92
102
reserved
Carozzi, V., Chiorazzi, A., Canta, A., Meregalli, C., Oggioni, N., Cavaletti, G., et al. (2015). Chemotherapy-induced peripheral neurotoxicity in immune-deficient mice: New useful ready-to-use animal models. EXPERIMENTAL NEUROLOGY, 264, 92-102 [10.1016/j.expneurol.2014.11.002].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/59129
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