Hepatitis C virus (HCV) easily undergoes genomic changes, thus accounting for the presence of different genotypes, with different geographic distributions and different outcomes of chronic hepatitis. Type 1b is frequently found in advanced diseases; however, since this genotype is the most prevalent in older patients, the association with advanced age and severity of the disease is confounding. The aim of this study was to assess changes in the prevalence of HCV genotypes by surveying a large population of chronic hepatitis C patients in Northern Italy, and to assess if the high prevalence of genotype 1b in older patients with advanced diseases simply reflects the duration of HCV infection, rather than intrinsic biological properties of HCV.
Roffi, L., Ricci, A., Ogliari, C., Scalori, A., Minola, E., Colloredo, G., et al. (1998). HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients. JOURNAL OF HEPATOLOGY, 29(5), 701-706 [10.1016/S0168-8278(98)80249-3].
HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients
PIPERNO, ALBERTO;MANCIA, GIUSEPPEUltimo
1998
Abstract
Hepatitis C virus (HCV) easily undergoes genomic changes, thus accounting for the presence of different genotypes, with different geographic distributions and different outcomes of chronic hepatitis. Type 1b is frequently found in advanced diseases; however, since this genotype is the most prevalent in older patients, the association with advanced age and severity of the disease is confounding. The aim of this study was to assess changes in the prevalence of HCV genotypes by surveying a large population of chronic hepatitis C patients in Northern Italy, and to assess if the high prevalence of genotype 1b in older patients with advanced diseases simply reflects the duration of HCV infection, rather than intrinsic biological properties of HCV.
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