Many agents have been reported to cause hemolytic anemia in glucose-6-phosphate dehydrogenase (G6PD) deficient subjects. We investigated whether cimetropium bromide, a new antispasmodic drug, can be safely given to these patients. In the first study, ten healthy volunteers were given 50 mg, p.o. 3 times per day, before meals for 1 week. Blood samples were drawn before and after treatment and stimulation of the hexose monophosphate shunt (HMS) was evaluated. No significant stimulation of HMS was observed. In a second study, 12 G6PD-deficient patients with spastic colon were given cimetropium bromide and placebo according to a double blind, cross-over design. None of the patients showed any significant abnormalities in any of the several hematologic parameters tested.

Piperno, A., Muzio, F., Imbimbo, B., Manoussakis, S., Daniotti, S., Fiorelli, G. (1987). Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY, 25(8), 464-467.

Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans

PIPERNO, ALBERTO
Primo
;
1987

Abstract

Many agents have been reported to cause hemolytic anemia in glucose-6-phosphate dehydrogenase (G6PD) deficient subjects. We investigated whether cimetropium bromide, a new antispasmodic drug, can be safely given to these patients. In the first study, ten healthy volunteers were given 50 mg, p.o. 3 times per day, before meals for 1 week. Blood samples were drawn before and after treatment and stimulation of the hexose monophosphate shunt (HMS) was evaluated. No significant stimulation of HMS was observed. In a second study, 12 G6PD-deficient patients with spastic colon were given cimetropium bromide and placebo according to a double blind, cross-over design. None of the patients showed any significant abnormalities in any of the several hematologic parameters tested.
Articolo in rivista - Articolo scientifico
Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Parasympatholytics; Scopolamine Derivatives
English
464
467
4
Piperno, A., Muzio, F., Imbimbo, B., Manoussakis, S., Daniotti, S., Fiorelli, G. (1987). Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY, 25(8), 464-467.
Piperno, A; Muzio, F; Imbimbo, B; Manoussakis, S; Daniotti, S; Fiorelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/58155
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