Many agents have been reported to cause hemolytic anemia in glucose-6-phosphate dehydrogenase (G6PD) deficient subjects. We investigated whether cimetropium bromide, a new antispasmodic drug, can be safely given to these patients. In the first study, ten healthy volunteers were given 50 mg, p.o. 3 times per day, before meals for 1 week. Blood samples were drawn before and after treatment and stimulation of the hexose monophosphate shunt (HMS) was evaluated. No significant stimulation of HMS was observed. In a second study, 12 G6PD-deficient patients with spastic colon were given cimetropium bromide and placebo according to a double blind, cross-over design. None of the patients showed any significant abnormalities in any of the several hematologic parameters tested.
Piperno, A., Muzio, F., Imbimbo, B., Manoussakis, S., Daniotti, S., & Fiorelli, G. (1987). Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY, 25(8), 464-467.
Citazione: | Piperno, A., Muzio, F., Imbimbo, B., Manoussakis, S., Daniotti, S., & Fiorelli, G. (1987). Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY, 25(8), 464-467. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Cimetropium bromide, a new antispasmodic agent, has no hemolytic effects in humans | |
Autori: | Piperno, A; Muzio, F; Imbimbo, B; Manoussakis, S; Daniotti, S; Fiorelli, G | |
Autori: | PIPERNO, ALBERTO (Primo) | |
Data di pubblicazione: | 1987 | |
Lingua: | English | |
Rivista: | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY | |
Appare nelle tipologie: | 01 - Articolo su rivista |