We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (v 18% of those without iron overload, P less than 0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.

Fargion, S., Piperno, A., Panaiotopoulos, N., Taddei, M., Fiorelli, G. (1985). Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene. BRITISH JOURNAL OF HAEMATOLOGY, 61(3), 487-490 [10.1111/j.1365-2141.1985.tb02852.x].

Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene

PIPERNO, ALBERTO
Secondo
;
1985

Abstract

We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (v 18% of those without iron overload, P less than 0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.
Articolo in rivista - Articolo scientifico
Adolescent; Adult; Aged; Female; Genes; HLA Antigens; HLA-A Antigens; HLA-A3 Antigen; HLA-B Antigens; Hemochromatosis; Humans; Iron; Male; Middle Aged; Thalassemia
English
487
490
4
Fargion, S., Piperno, A., Panaiotopoulos, N., Taddei, M., Fiorelli, G. (1985). Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene. BRITISH JOURNAL OF HAEMATOLOGY, 61(3), 487-490 [10.1111/j.1365-2141.1985.tb02852.x].
Fargion, S; Piperno, A; Panaiotopoulos, N; Taddei, M; Fiorelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/58141
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