Basic ferritin (liver-type) was measured in erythrocytes of subjects with alpha- and beta-thalassemia trait, thalassemia intermedia and Cooley's disease, and compared with normals and patients with abnormal iron metabolism without erythrocyte metabolic defect (iron deficiency anemia and idiopathic hemochromatosis). In all the thalassemic syndromes considered, erythrocyte ferritin was significantly higher than in normals (p less than 0.001) and increased progressively with the increasing 'severity' of the thalassemic disorder. In both thalassemic and non-thalassemic subjects, erythrocyte ferritin levels were related to body iron status, but in the thalassemic group, the increased erythrocyte ferritin values seemed also to be closely related to the intracellular metabolic abnormality. The severity of the defect in globin chain synthesis seemed to play an important role in determining ferritin accumulation in red cells of thalassemic subjects.
Piperno, A., Taddei, M., Sampietro, M., Fargion, S., Arosio, P., & Fiorelli, G. (1984). Erythrocyte ferritin in thalassemia syndromes. ACTA HAEMATOLOGICA, 71(4), 251-256.
Citazione: | Piperno, A., Taddei, M., Sampietro, M., Fargion, S., Arosio, P., & Fiorelli, G. (1984). Erythrocyte ferritin in thalassemia syndromes. ACTA HAEMATOLOGICA, 71(4), 251-256. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Erythrocyte ferritin in thalassemia syndromes |
Autori: | Piperno, A; Taddei, M; Sampietro, M; Fargion, S; Arosio, P; Fiorelli, G |
Autori: | PIPERNO, ALBERTO (Primo) |
Data di pubblicazione: | 1984 |
Lingua: | English |
Rivista: | ACTA HAEMATOLOGICA |
Appare nelle tipologie: | 01 - Articolo su rivista |