In this paper, we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are natural for cancer therapies, and we derive necessary conditions for optimality.
Garavello, M., Rossi, E. (2025). Optimal control problems for a parabolic system inspired by a cancer therapy. ZEITSCHRIFT FUR ANALYSIS UND IHRE ANWENDUNGEN, 44(3/4), 355-388 [10.4171/zaa/1775].
Optimal control problems for a parabolic system inspired by a cancer therapy
Garavello M.;
2025
Abstract
In this paper, we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are natural for cancer therapies, and we derive necessary conditions for optimality.
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