Percutaneous ablation of the renal nerves [renal denervation (RDN)] has recently become available for treatment of (therapy-resistant) hypertension. In this review, the potential importance of RDN for patients with chronic kidney disease (CKD) is discussed. An overview of the role of the renal nerves is given, and the role of the kidneys as both generators and recipients of sympathetic hyperactivity is described. The clinical relevance of increased sympathetic nervous system activity in CKD is reviewed, and the effects of conventional treatment on sympathetic hyperactivity are summarized. Next, we present the current knowledge on the effect of RDN in CKD from both experimental and clinical studies. Finally, we discuss how this knowledge may help us in predicting the effect of RDN in hypertensive patients and ways to monitor the effect of the procedure itself.

de Beus, E., de Jager, R., Joles, J., Grassi, G., Blankestijn, P. (2014). Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?. JOURNAL OF HYPERTENSION, 32(9), 1751-1761 [10.1097/HJH.0000000000000210].

Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?

GRASSI, GUIDO
Penultimo
;
2014

Abstract

Percutaneous ablation of the renal nerves [renal denervation (RDN)] has recently become available for treatment of (therapy-resistant) hypertension. In this review, the potential importance of RDN for patients with chronic kidney disease (CKD) is discussed. An overview of the role of the renal nerves is given, and the role of the kidneys as both generators and recipients of sympathetic hyperactivity is described. The clinical relevance of increased sympathetic nervous system activity in CKD is reviewed, and the effects of conventional treatment on sympathetic hyperactivity are summarized. Next, we present the current knowledge on the effect of RDN in CKD from both experimental and clinical studies. Finally, we discuss how this knowledge may help us in predicting the effect of RDN in hypertensive patients and ways to monitor the effect of the procedure itself.
Articolo in rivista - Articolo scientifico
Renal denervation, kidney disease
English
2014
32
9
1751
1761
none
de Beus, E., de Jager, R., Joles, J., Grassi, G., Blankestijn, P. (2014). Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?. JOURNAL OF HYPERTENSION, 32(9), 1751-1761 [10.1097/HJH.0000000000000210].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/56909
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