Objective: Obstructive sleep apnoea (OSA) is characterized by a marked sympathetic overdrive, as documented by the elevated sympathetic nerve firing rate detected in peripheral muscle nerves. No data are available, however, on the behaviour of sympathetic drive in vascular regional districts other than the muscle circulation. Design and methods: In 66 middle-aged normotensive individuals classified according to BMI, waist-to-hip ratio and apnoea-hypopnea index as lean individuals without (n=20) or with (n=14) OSA and as obese individuals without (n=13) or with (n=19) OSA, we measured blood pressure, heart rate, muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA), respectively, via microneurography. Measurements also included SSNA responses to an emotional stimulus. Results: The four groups were matched for age, sex and blood pressure values. Both in lean and obese individuals, presence of OSA was accompanied by MSNA values significantly greater than thos...
Grassi, G., Seravalle, G., Brambilla, G., Buzzi, S., Volpe, M., Cesana, F., et al. (2014). Regional differences in sympathetic activation in lean and obese normotensive individuals with obstructive sleep apnoea. JOURNAL OF HYPERTENSION, 32(2), 383-388 [10.1097/HJH.0000000000000034].
Regional differences in sympathetic activation in lean and obese normotensive individuals with obstructive sleep apnoea
GRASSI, GUIDO;BRAMBILLA, GIANMARIA;BUZZI, SILVIA;VOLPE, MARCO ANTONIO VALENTINO;CESANA, FRANCESCA;DELL'ORO, RAFFAELLA;MANCIA, GIUSEPPE
2014
Abstract
Objective: Obstructive sleep apnoea (OSA) is characterized by a marked sympathetic overdrive, as documented by the elevated sympathetic nerve firing rate detected in peripheral muscle nerves. No data are available, however, on the behaviour of sympathetic drive in vascular regional districts other than the muscle circulation. Design and methods: In 66 middle-aged normotensive individuals classified according to BMI, waist-to-hip ratio and apnoea-hypopnea index as lean individuals without (n=20) or with (n=14) OSA and as obese individuals without (n=13) or with (n=19) OSA, we measured blood pressure, heart rate, muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA), respectively, via microneurography. Measurements also included SSNA responses to an emotional stimulus. Results: The four groups were matched for age, sex and blood pressure values. Both in lean and obese individuals, presence of OSA was accompanied by MSNA values significantly greater than thos...
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