Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. © The Author(s) 2013.

Fenoglio, C., Ridolfi, E., Cantoni, C., De Riz, M., Bonsi, R., Serpente, M., et al. (2013). Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. MULTIPLE SCLEROSIS, 19(14), 1938-1942 [10.1177/1352458513485654].

Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

VILLA, CHIARA;
2013

Abstract

Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. © The Author(s) 2013.
Articolo in rivista - Articolo scientifico
miRNAs, multiple sclerosis
English
2013
19
14
1938
1942
none
Fenoglio, C., Ridolfi, E., Cantoni, C., De Riz, M., Bonsi, R., Serpente, M., et al. (2013). Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. MULTIPLE SCLEROSIS, 19(14), 1938-1942 [10.1177/1352458513485654].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/56664
Citazioni
  • Scopus 97
  • ???jsp.display-item.citation.isi??? 91
Social impact