A Model for Zebrafish Ventricular Action Potential

From the '90s, the interest in the use of zebrafish has exponentially grown thanks to the numerous characteristics, very close to the human ones, that make this little fish very attractive in different fields. Thus, zebrafish has been increasingly proposed as a pharmacological and genetic screening model. The growing interest and the relevance of this animal model motivate the development of a mathematical model of the action potential of the zebrafish to facilitate the understanding of the mechanisms associated with its electrophysiological behavior and how they correlated with those observed in humans. This work presents the first attempt to develop a mathematical model of the adult zebrafish action potential. The model is based on the Ten Tusscher formulation of the action potential of human cardiomyocyte in which the main currents have been reparametrized to be adapted to those of the zebrafish, while extending the model to account for the T-type calcium current present in the zebrafish. Preliminary results of the proposed model show an action potential morphology in good agreement with experimental data.