Introduction: Impairment of decision making in relapsing remitting multiple sclerosis is still controversial, and its neuropsychological correlates have never been explored thoroughly, especially in patients with minimal physical and cognitive deficits. In the present study we investigated the cognitive underpinnings of decision making under ambiguous and explicit conditions in patients with very mild relapsing remitting multiple sclerosis, using a dice and a card gambling game. Method: The study sample included 60 patients and 35 healthy subjects. In the Game of Dice Task, winning and losing probabilities are obvious to the subject, while in the Iowa Gambling Task they are initially ambiguous and have to be gradually identified. Performance at the two tasks was correlated with scores obtained at tests investigating cognitive processing speed, memory, language and executive functions. Results: Patients' performance did not differ from that of controls at either gambling task. There was only a trend for them to be significantly slower than healthy subjects in progressively recognizing advantageous decks in the Iowa Gambling Task. While the Game of Dice was unrelated to neuropsychological tests, predictors of performance at the Iowa task were Letter Fluency and the Symbol Digit Modalities Test for the initial, under-ambiguity, trials and the Wisconsin Card Sorting Test for the last, purely under-risk, trials. Conclusions: Our results suggest that high-functioning patients with relapsing remitting multiple sclerosis are substantially capable of making advantageous decisions, even if they may be slower in processing options and shifting strategy when selection criteria are not explicit.

Cogo, M., Rota, S., Fusco, M., Mapelli, C., Ferri, F., Appollonio, I., et al. (2014). Cognitive correlates of under-ambiguity and under-risk decision making in high-functioning patients with relapsing remitting multiple sclerosis. NEUROPSYCHOLOGY, DEVELOPMENT, AND COGNITION. SECTION A, JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 36(10), 1066-1075 [10.1080/13803395.2014.971718].

Cognitive correlates of under-ambiguity and under-risk decision making in high-functioning patients with relapsing remitting multiple sclerosis

COGO, MARTINA GAIA;ROTA, STEFANIA;FUSCO, MARIA LETIZIA;MAPELLI, CRISTINA;FERRI, FRANCESCA;APPOLLONIO, ILDEBRANDO;ISELLA, VALERIA
2014

Abstract

Introduction: Impairment of decision making in relapsing remitting multiple sclerosis is still controversial, and its neuropsychological correlates have never been explored thoroughly, especially in patients with minimal physical and cognitive deficits. In the present study we investigated the cognitive underpinnings of decision making under ambiguous and explicit conditions in patients with very mild relapsing remitting multiple sclerosis, using a dice and a card gambling game. Method: The study sample included 60 patients and 35 healthy subjects. In the Game of Dice Task, winning and losing probabilities are obvious to the subject, while in the Iowa Gambling Task they are initially ambiguous and have to be gradually identified. Performance at the two tasks was correlated with scores obtained at tests investigating cognitive processing speed, memory, language and executive functions. Results: Patients' performance did not differ from that of controls at either gambling task. There was only a trend for them to be significantly slower than healthy subjects in progressively recognizing advantageous decks in the Iowa Gambling Task. While the Game of Dice was unrelated to neuropsychological tests, predictors of performance at the Iowa task were Letter Fluency and the Symbol Digit Modalities Test for the initial, under-ambiguity, trials and the Wisconsin Card Sorting Test for the last, purely under-risk, trials. Conclusions: Our results suggest that high-functioning patients with relapsing remitting multiple sclerosis are substantially capable of making advantageous decisions, even if they may be slower in processing options and shifting strategy when selection criteria are not explicit.
Articolo in rivista - Articolo scientifico
Scientifica
Decision making; Executive functions; Game of Dice Task; Iowa Gambling Task; Multiple sclerosis
English
Cogo, M., Rota, S., Fusco, M., Mapelli, C., Ferri, F., Appollonio, I., et al. (2014). Cognitive correlates of under-ambiguity and under-risk decision making in high-functioning patients with relapsing remitting multiple sclerosis. NEUROPSYCHOLOGY, DEVELOPMENT, AND COGNITION. SECTION A, JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 36(10), 1066-1075 [10.1080/13803395.2014.971718].
Cogo, M; Rota, S; Fusco, M; Mapelli, C; Ferri, F; Appollonio, I; Isella, V
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/56305
Citazioni
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
Social impact