During asymmetric cell division, spindle positioning is critical to ensure the unequal segregation of polarity factors and generate daughter cells with different sizes or fates. In budding yeast the boundary between mother and daughter cell resides at the bud neck, where cytokinesis takes place at the end of the cell cycle. Since budding and bud neck formation occur much earlier than bipolar spindle formation, spindle positioning is a finely regulated process. A surveillance device called the SPOC (spindle position checkpoint) oversees this process and delays mitotic exit and cytokinesis until the spindle is properly oriented along the division axis, thus ensuring genome stability.

Fraschini, R., Venturetti, M., Chiroli, E., & Piatti, S. (2008). The spindle position checkpoint: how to deal with spindle misalignment during asymmetric cell division in budding yeast. BIOCHEMICAL SOCIETY TRANSACTIONS, 36, 416-420 [10.1042/BST0360416].

The spindle position checkpoint: how to deal with spindle misalignment during asymmetric cell division in budding yeast

FRASCHINI, ROBERTA;PIATTI, SIMONETTA
2008-06

Abstract

During asymmetric cell division, spindle positioning is critical to ensure the unequal segregation of polarity factors and generate daughter cells with different sizes or fates. In budding yeast the boundary between mother and daughter cell resides at the bud neck, where cytokinesis takes place at the end of the cell cycle. Since budding and bud neck formation occur much earlier than bipolar spindle formation, spindle positioning is a finely regulated process. A surveillance device called the SPOC (spindle position checkpoint) oversees this process and delays mitotic exit and cytokinesis until the spindle is properly oriented along the division axis, thus ensuring genome stability.
Articolo in rivista - Articolo scientifico
spindle position checkpoint
English
Fraschini, R., Venturetti, M., Chiroli, E., & Piatti, S. (2008). The spindle position checkpoint: how to deal with spindle misalignment during asymmetric cell division in budding yeast. BIOCHEMICAL SOCIETY TRANSACTIONS, 36, 416-420 [10.1042/BST0360416].
Fraschini, R; Venturetti, M; Chiroli, E; Piatti, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/5575
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