Pixantrone maleate - Topoisomerase II inhibitor DNA intercalating agent oncolytic

Pixantrone is a noncardiotoxic aza-anthracenedione antineoplastic agent related to mitoxantrone. They share the same cytotoxic mechanism of action, interacting with DNA as intercalating agents via inhibition of topoisomerase II. The efficacy of pixantrone as an antineoplastic drug has been demonstrated in phase II/III clinical studies. Pixantrone is also extremely interesting as a putative immunosuppressant; at equiactive doses it is less cardiotoxic than mitoxantrone and it shows similar in vitro and in vivo immunological effects.