Purpose of review: To evaluate the rationale and the pharmacologic options for sedating neurointensive care patients. Recent findings: Sedation is a fundamental element in the neurointensive care unit. Even if the sedative strategy in the neurointensive care unit shares the same general aims with intensive care, the characteristics of the patients in the neurointensive care unit pose other unique challenges and some specific indications. The primary aim of neurointensive care is to maintain adequate cerebral perfusion pressure, to control intracranial pressure, and to maintain an adequate mean arterial pressure. Reducing the brain's metabolic demand is an important treatment strategy, and analgesic and sedative agents are used to prevent undesirable increases in intracranial pressure. There are many different pharmacologic agents available, each with distinct advantages and disadvantages. Summary: The pharmacokinetic and pharmacologic effects of the available sedatives used in neurointensive care patients are reviewed.

Citerio, G., Cormio, M. (2003). Sedation in neurointensive care: Advances in understanding and practice. CURRENT OPINION IN CRITICAL CARE, 9(2), 120-126 [10.1097/00075198-200304000-00007].

Sedation in neurointensive care: Advances in understanding and practice

CITERIO, GIUSEPPE
Primo
;
CORMIO, MANUELA
Ultimo
2003

Abstract

Purpose of review: To evaluate the rationale and the pharmacologic options for sedating neurointensive care patients. Recent findings: Sedation is a fundamental element in the neurointensive care unit. Even if the sedative strategy in the neurointensive care unit shares the same general aims with intensive care, the characteristics of the patients in the neurointensive care unit pose other unique challenges and some specific indications. The primary aim of neurointensive care is to maintain adequate cerebral perfusion pressure, to control intracranial pressure, and to maintain an adequate mean arterial pressure. Reducing the brain's metabolic demand is an important treatment strategy, and analgesic and sedative agents are used to prevent undesirable increases in intracranial pressure. There are many different pharmacologic agents available, each with distinct advantages and disadvantages. Summary: The pharmacokinetic and pharmacologic effects of the available sedatives used in neurointensive care patients are reviewed.
Articolo in rivista - Articolo scientifico
Benzodiazepines; Head injury; Intracranial pressure; Neurointensive care; Neurologic examination; Opioids; Propofol; Sedation;
English
2003
9
2
120
126
reserved
Citerio, G., Cormio, M. (2003). Sedation in neurointensive care: Advances in understanding and practice. CURRENT OPINION IN CRITICAL CARE, 9(2), 120-126 [10.1097/00075198-200304000-00007].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/55225
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