The results of randomized clinical trials (RCTs) are frequently assessed with the fragility index (FI). Although the information provided by FI may supplement the p value, this indicator presents intrinsic weaknesses and shortcomings. In this article, we establish an analysis of fragility within a broader framework so that it can reliably complement the information provided by the p value. This perspective is named the analysis of strength. We first propose a new strength index (SI), which can be adopted in normal distribution settings. This measure can be obtained for both significance and nonsignificance and is straightforward to calculate, thus presenting compelling advantages over FI, starting from the presence of a threshold. The case of time-to-event outcomes is also addressed. Then, beyond the p value, we develop the analysis of strength using likelihood ratios from Royall's statistical evidence viewpoint. A new R package is provided for performing strength calculations, and a simulation study is conducted to explore the behavior of SI and the likelihood-based indicator empirically across different settings. The newly proposed analysis of strength is applied in the assessment of the results of three recent trials involving the treatment of COVID-19.

Quatto, P., Ripamonti, E., Marasini, D. (2025). Beyond the Fragility Index. PHARMACEUTICAL STATISTICS, 24(2 (March/April 2025)) [10.1002/pst.2452].

Beyond the Fragility Index

Quatto, P;Ripamonti, E;Marasini, D
2025

Abstract

The results of randomized clinical trials (RCTs) are frequently assessed with the fragility index (FI). Although the information provided by FI may supplement the p value, this indicator presents intrinsic weaknesses and shortcomings. In this article, we establish an analysis of fragility within a broader framework so that it can reliably complement the information provided by the p value. This perspective is named the analysis of strength. We first propose a new strength index (SI), which can be adopted in normal distribution settings. This measure can be obtained for both significance and nonsignificance and is straightforward to calculate, thus presenting compelling advantages over FI, starting from the presence of a threshold. The case of time-to-event outcomes is also addressed. Then, beyond the p value, we develop the analysis of strength using likelihood ratios from Royall's statistical evidence viewpoint. A new R package is provided for performing strength calculations, and a simulation study is conducted to explore the behavior of SI and the likelihood-based indicator empirically across different settings. The newly proposed analysis of strength is applied in the assessment of the results of three recent trials involving the treatment of COVID-19.
Articolo in rivista - Articolo scientifico
fragility index; likelihood ratio; randomized clinical trial; strength index;
English
21-nov-2024
2025
24
2 (March/April 2025)
e2452
open
Quatto, P., Ripamonti, E., Marasini, D. (2025). Beyond the Fragility Index. PHARMACEUTICAL STATISTICS, 24(2 (March/April 2025)) [10.1002/pst.2452].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/550846
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