We analyzed scores obtained at the Neuropsychiatric Inventory (NPI) by 20 patients with posterior cortical atrophy (PCA) and contrasted it with 20 patients having Alzheimer disease (AD). Patients with hallucinations and delusions were not included due to the high probability of a diagnosis of Lewy body disease. Prevalence of behavioral and psychological symptoms (BPSD) was 95% in the PCA group, the most frequent being apathy and anxiety. Cluster analysis on NPI subscales highlighted a behavioral subsyndrome characterized by agitated temper and irritability. Depression, anxiety, and apathy did not cluster with any other BPSD nor with each other. The PCA group showed a significantly higher proportion of anxious patients and worse anxiety score than patients with AD. No correlation was found between NPI data and demographic, clinical, or neuropsychological features nor were there significant differences for the same variables between anxious and nonanxious cases with PCA. In agreement with anecdotal reports, anxiety seems particularly relevant in PCA.

Isella, V., Villa, G., Mapelli, C., Ferri, F., Appollonio, I., Ferrarese, C. (2015). The Neuropsychiatric Profile of Posterior Cortical Atrophy. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 28(2), 136-144 [10.1177/0891988714554713].

The Neuropsychiatric Profile of Posterior Cortical Atrophy

ISELLA, VALERIA
Primo
;
MAPELLI, CRISTINA;FERRI, FRANCESCA;APPOLLONIO, ILDEBRANDO
Penultimo
;
FERRARESE, CARLO
Ultimo
2015

Abstract

We analyzed scores obtained at the Neuropsychiatric Inventory (NPI) by 20 patients with posterior cortical atrophy (PCA) and contrasted it with 20 patients having Alzheimer disease (AD). Patients with hallucinations and delusions were not included due to the high probability of a diagnosis of Lewy body disease. Prevalence of behavioral and psychological symptoms (BPSD) was 95% in the PCA group, the most frequent being apathy and anxiety. Cluster analysis on NPI subscales highlighted a behavioral subsyndrome characterized by agitated temper and irritability. Depression, anxiety, and apathy did not cluster with any other BPSD nor with each other. The PCA group showed a significantly higher proportion of anxious patients and worse anxiety score than patients with AD. No correlation was found between NPI data and demographic, clinical, or neuropsychological features nor were there significant differences for the same variables between anxious and nonanxious cases with PCA. In agreement with anecdotal reports, anxiety seems particularly relevant in PCA.
Articolo in rivista - Articolo scientifico
anxiety; behavioral disturbance; cognitive decline; cognitive impairment; dementia; psychosis
English
20-ott-2014
2015
28
2
136
144
0891988714554713
none
Isella, V., Villa, G., Mapelli, C., Ferri, F., Appollonio, I., Ferrarese, C. (2015). The Neuropsychiatric Profile of Posterior Cortical Atrophy. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 28(2), 136-144 [10.1177/0891988714554713].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/55009
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