This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

Zalevskaja, K., Ojala, K., Petrov, A., Haupt, S., Sunde, L., Bernstein, I., et al. (2025). Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database. BRITISH JOURNAL OF SURGERY, 112(4) [10.1093/bjs/znaf061].

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Fruscio, R;
2025

Abstract

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.
Articolo in rivista - Articolo scientifico
Lynch syndrome
English
15-apr-2025
2025
112
4
znaf061
none
Zalevskaja, K., Ojala, K., Petrov, A., Haupt, S., Sunde, L., Bernstein, I., et al. (2025). Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database. BRITISH JOURNAL OF SURGERY, 112(4) [10.1093/bjs/znaf061].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/549903
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