Magnesium offers theoretic vascular and neuroprotective benefits for patients with subarachnoid hemorrhage. An electronic literature search was conducted to identify original research studies describing intravenous magnesium treatment in patients with SAH published in English between January 1990 and October 2010. Seventeen articles were identified and reviewed, including one phase III randomized-controlled clinical trial and six phase II randomized-controlled trials. Study quality was low for most of the included studies, with the phase III trial considered to be of moderate quality. Due to inconsistently reported benefits and the occurrence of side effects, phase II data suggested that intravenous magnesium for SAH provided either no overall net benefit or uncertain tradeoffs. Benefit was likewise not supported in the single phase III clinical trial. © Springer Science+Business Media, LLC 2011.

Suarez, J., Citerio, G. (2011). Magnesium sulfate administration in subarachnoid hemorrhage. NEUROCRITICAL CARE, 15(2), 302-307 [10.1007/s12028-011-9603-y].

Magnesium sulfate administration in subarachnoid hemorrhage

CITERIO, GIUSEPPE
2011

Abstract

Magnesium offers theoretic vascular and neuroprotective benefits for patients with subarachnoid hemorrhage. An electronic literature search was conducted to identify original research studies describing intravenous magnesium treatment in patients with SAH published in English between January 1990 and October 2010. Seventeen articles were identified and reviewed, including one phase III randomized-controlled clinical trial and six phase II randomized-controlled trials. Study quality was low for most of the included studies, with the phase III trial considered to be of moderate quality. Due to inconsistently reported benefits and the occurrence of side effects, phase II data suggested that intravenous magnesium for SAH provided either no overall net benefit or uncertain tradeoffs. Benefit was likewise not supported in the single phase III clinical trial. © Springer Science+Business Media, LLC 2011.
Articolo in rivista - Articolo scientifico
Delayed cerebral ischemia; Infusion; Intravenous; Neuroprotection; Vasospasm; Acute Disease; Anticonvulsants; Brain Ischemia; Humans; Intensive Care; Magnesium Sulfate; Neuroprotective Agents; Subarachnoid Hemorrhage; Vasospasm, Intracranial; Neurology (clinical); Critical Care and Intensive Care Medicine
English
2011
15
2
302
307
reserved
Suarez, J., Citerio, G. (2011). Magnesium sulfate administration in subarachnoid hemorrhage. NEUROCRITICAL CARE, 15(2), 302-307 [10.1007/s12028-011-9603-y].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/54849
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