Objective: Paroxysmal sympathetic hyperactivity (PSH) is widely described as occurring during intensive care, but in a number of patients it may last longer into the rehabilitation phase. Furthermore, drug therapy has been based on isolated observations. In this study, our aims are to describe a group of 26 pediatric rehabilitation patients with PSH and to quantify the effect of several drugs used to suppress PSH episodes. Setting: Neurorehabilitation unit of IRCCS Eugenio Medea, Bosisio Parini (LC), Italy. Participants: A total of 407 pediatric patients with postacute acquired brain injury, 26 of which had PSH. Design: Retrospective cohort study. Main Measures: Descriptive demographic and clinical data. Odds ratios quantification of the efficacy of drug therapies administered acutely to suppress PSH episodes. Results: PSH was associated with a longer duration of coma and a greater incidence of death. When administered acutely to suppress PSH episodes, the best drugs were clonazepam, hydroxyzine, and delorazepam, while analgesic drugs showed little efficacy. Conclusions: PSH, whether causative or not, is associated with a worse long-term course in rehabilitation. Clinical management of PSH may be helped by a number of acutely administered drug therapies.
Pozzi, M., Conti, V., Locatelli, F., Galbiati, S., Radice, S., Citerio, G., et al. (2015). Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Clinical Factors and Acute Pharmacological Management. JOURNAL OF HEAD TRAUMA REHABILITATION, 30(5), 357-363.
Citazione: | Pozzi, M., Conti, V., Locatelli, F., Galbiati, S., Radice, S., Citerio, G., et al. (2015). Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Clinical Factors and Acute Pharmacological Management. JOURNAL OF HEAD TRAUMA REHABILITATION, 30(5), 357-363. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Clinical Factors and Acute Pharmacological Management |
Autori: | Pozzi, M; Conti, V; Locatelli, F; Galbiati, S; Radice, S; Citerio, G; Clementi, E; Strazzer, S |
Autori: | POZZI, MARCO (Primo) |
Data di pubblicazione: | 2015 |
Lingua: | English |
Rivista: | JOURNAL OF HEAD TRAUMA REHABILITATION |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/HTR.0000000000000084 |
Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Journal of Head Trauma Rehabilitation 2014 Pozzi.pdf | N/A | Administrator Richiedi una copia |