The idea that G protein-coupled receptors (GPCRs) may undergo homo- or hetero-oligomerization, although highly controversial up to a few years ago, has recently gained wide acceptance. The recognition that GPCRs may exhibit either dimeric or oligomeric structures is based upon a large body of biochemical and biophysical evidence. While much effort has been spent to demonstrate the mechanism(s) by which GPCRs interact with each other, the physiological relevance of this phenomenon remains rather elusive. GPCR oligomerization has been proposed to play a role in receptor ontogeny by either chaperoning protein folding or controlling trafficking to the cell surface. However, the acquisition of these roles does not rule out the possibility that oligomeric receptors may have additional functions, once they are brought to the cell surface. Herein, we propose that protein-protein as well as protein-lipid interactions may provide the structural basis for organizing distinct cell compartments along the plasma membrane where different extracellular signals may be perceived and discriminated. © 2007 The Authors

Maggio, R., Innamorati, G., & Parenti, M. (2007). G protein-coupled receptor oligomerization provides the framework for signal discrimination. JOURNAL OF NEUROCHEMISTRY, 103(5), 1741-1752 [10.1111/j.1471-4159.2007.04896.x].

G protein-coupled receptor oligomerization provides the framework for signal discrimination

PARENTI, MARCO DOMENICO
2007

Abstract

The idea that G protein-coupled receptors (GPCRs) may undergo homo- or hetero-oligomerization, although highly controversial up to a few years ago, has recently gained wide acceptance. The recognition that GPCRs may exhibit either dimeric or oligomeric structures is based upon a large body of biochemical and biophysical evidence. While much effort has been spent to demonstrate the mechanism(s) by which GPCRs interact with each other, the physiological relevance of this phenomenon remains rather elusive. GPCR oligomerization has been proposed to play a role in receptor ontogeny by either chaperoning protein folding or controlling trafficking to the cell surface. However, the acquisition of these roles does not rule out the possibility that oligomeric receptors may have additional functions, once they are brought to the cell surface. Herein, we propose that protein-protein as well as protein-lipid interactions may provide the structural basis for organizing distinct cell compartments along the plasma membrane where different extracellular signals may be perceived and discriminated. © 2007 The Authors
No
Articolo in rivista - Articolo scientifico
Scientifica
GPCR
English
1741
1752
12
Maggio, R., Innamorati, G., & Parenti, M. (2007). G protein-coupled receptor oligomerization provides the framework for signal discrimination. JOURNAL OF NEUROCHEMISTRY, 103(5), 1741-1752 [10.1111/j.1471-4159.2007.04896.x].
Maggio, R; Innamorati, G; Parenti, M
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/5436
Citazioni
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 38
Social impact