Glioblastomas (GBMs) contain transformed, self-maintaining, multipotent, tumour-initiating cancer stem cells, whose identification has radically changed our perspective on the physiology of these tumours. Currently, it is unknown whether multiple types of transformed precursors, which display alternative sets of the complement of properties of true cancer stem cells, can be found in a GBM. If different subsets of such cancer stem-like cells (CSCs) do exist, they might represent distinct cell targets, with a differential therapeutic importance, also depending on their characteristics and lineage relationship. Here, we report the presence of two types of CSCs within different regions of the same human GBM. Cytogenetic and molecular analysis shows that the two types of CSCs bear quite diverse tumorigenic potential and distinct genetic anomalies, and, yet, derive from common ancestor cells. This provides critical information to unravel the development of CSCs and the key molecular/genetic components underpinning tumorigenicity in human GBMs. © 2009 Macmillan Publishers Limited. All rights reserved.

Piccirillo, S., Combi, R., Cajola, L., Patrizi, A., Redaelli, S., Bentivegna, A., et al. (2009). Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. ONCOGENE, 28(15), 1807-1811 [10.1038/onc.2009.27].

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

COMBI, ROMINA;REDAELLI, SERENA;BENTIVEGNA, ANGELA;DALPRA', LEDA;VESCOVI, ANGELO LUIGI
2009

Abstract

Glioblastomas (GBMs) contain transformed, self-maintaining, multipotent, tumour-initiating cancer stem cells, whose identification has radically changed our perspective on the physiology of these tumours. Currently, it is unknown whether multiple types of transformed precursors, which display alternative sets of the complement of properties of true cancer stem cells, can be found in a GBM. If different subsets of such cancer stem-like cells (CSCs) do exist, they might represent distinct cell targets, with a differential therapeutic importance, also depending on their characteristics and lineage relationship. Here, we report the presence of two types of CSCs within different regions of the same human GBM. Cytogenetic and molecular analysis shows that the two types of CSCs bear quite diverse tumorigenic potential and distinct genetic anomalies, and, yet, derive from common ancestor cells. This provides critical information to unravel the development of CSCs and the key molecular/genetic components underpinning tumorigenicity in human GBMs. © 2009 Macmillan Publishers Limited. All rights reserved.
Articolo in rivista - Articolo scientifico
brain tumours, cancer stem-like cells, tumorigenicity
English
1807
1811
Piccirillo, S., Combi, R., Cajola, L., Patrizi, A., Redaelli, S., Bentivegna, A., et al. (2009). Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. ONCOGENE, 28(15), 1807-1811 [10.1038/onc.2009.27].
Piccirillo, S; Combi, R; Cajola, L; Patrizi, A; Redaelli, S; Bentivegna, A; Baronchelli, S; Maira, G; Pollo, B; Mangiola, A; Dimeco, F; Dalpra', L; Vescovi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/5409
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