PURPOSE:: Positron emission tomography/computed tomography (PET/CT) with C-11 choline has been used for staging, restaging, and follow-up of various tumors, whereas its role for imaging meningiomas has only been preliminarily explored. The aim of this study was to compare C-11 choline and F-18 fluorodeoxyglucose (F-18 FDG) uptake in meningiomas and relate these findings to the histopathological analysis. METHODS:: Two sequential three-dimensional PET/CT scans with 370 MBq (10 mCi) of C-11 choline and 370 MBq (10 mCi) of F-18 FDG were performed 2 hours apart in 7 patients with histologically confirmed meningiomas. Five patients had WHO grade I and 2 had WHO grade II meningioma. For each scan, two-dimensional regions of interest were drawn on tumor boundaries and on the contralateral side on CT images and copied to the corresponding PET images. SUVmax and tumor-to-background ratio were calculated. RESULTS:: Relative to the contralateral side, C-11 choline uptake was increased in all meningiomas, whereas F-18 FDG uptake was decreased in 6 patients and increased in 1 of the 2 patients with grade II meningiomas. In the whole group, SUVmax of C-11 choline and F-18 FDG were 3.6 +/- 1.3 and 5.7 +/- 1.3, respectively. The tumor-to-background ratio for C-11 choline was much higher than that for F-18 FDG (5.3 +/- 0.8 vs. 0.9 +/- 0.2, respectively) (P < 0.001). The uptake of C-11 choline was higher in patients with grade II than in grade I meningiomas. CONCLUSIONS:: These preliminary results suggest that C-11 choline may better image meningiomas in comparison with F-18 FDG. Clinical applications of C-11 choline PET/CT for grading and follow-up of meningiomas need to be assessed in further studies.
Giovacchini, G., Fallanca, F., Landoni, C., Gianolli, L., Picozzi, P., Attuati, L., et al. (2009). C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience. CLINICAL NUCLEAR MEDICINE, 34(1), 7-10 [10.1097/RLU.0b013e31818f4369].
|Citazione:||Giovacchini, G., Fallanca, F., Landoni, C., Gianolli, L., Picozzi, P., Attuati, L., et al. (2009). C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience. CLINICAL NUCLEAR MEDICINE, 34(1), 7-10 [10.1097/RLU.0b013e31818f4369].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience|
|Autori:||Giovacchini, G; Fallanca, F; Landoni, C; Gianolli, L; Picozzi, P; Attuati, L; Terreni, M; Picchio, M; Messa, MC; Fazio, F|
|Data di pubblicazione:||2009|
|Rivista:||CLINICAL NUCLEAR MEDICINE|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/RLU.0b013e31818f4369|
|Appare nelle tipologie:||01 - Articolo su rivista|