Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining with LC3 antibody was performed on 40 placentas from uneventful term singleton pregnancies with umbilical artery pH ≤ 7.00 at birth; semi-quantitative analysis was carried-out to estimate autophagy level. 6/40 (15%) neonates developed NE. Placentas from newborns with NE exhibited a higher LC3 expression. Autophagy protein expression in placentas with severe acidosis is a potential marker for poor outcome

Avagliano, L., Danti, L., Doi, P., Felis, S., Guala, M., Locatelli, A., et al. (2013). Autophagy in placentas from acidotic newborns: An immunohistochemical study of LC3 expression. PLACENTA, 34(11), 1091-1094 [10.1016/j.placenta.2013.09.004].

Autophagy in placentas from acidotic newborns: An immunohistochemical study of LC3 expression

LOCATELLI, ANNA;PLEVANI, CRISTINA;
2013

Abstract

Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining with LC3 antibody was performed on 40 placentas from uneventful term singleton pregnancies with umbilical artery pH ≤ 7.00 at birth; semi-quantitative analysis was carried-out to estimate autophagy level. 6/40 (15%) neonates developed NE. Placentas from newborns with NE exhibited a higher LC3 expression. Autophagy protein expression in placentas with severe acidosis is a potential marker for poor outcome
Articolo in rivista - Articolo scientifico
Scientifica
autophagy, encephalopathy, placenta
English
Avagliano, L., Danti, L., Doi, P., Felis, S., Guala, M., Locatelli, A., et al. (2013). Autophagy in placentas from acidotic newborns: An immunohistochemical study of LC3 expression. PLACENTA, 34(11), 1091-1094 [10.1016/j.placenta.2013.09.004].
Avagliano, L; Danti, L; Doi, P; Felis, S; Guala, M; Locatelli, A; Maffeo, I; Mecacci, F; Plevani, C; Simeone, S; Bulfamante, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/53485
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