To the Editor: In addition to the limitations of the Antibiotic Prophylaxis and Renal Damage in Congenital Abnormalities of the Kidney and Urinary Tract (PREDICT) trial by Morello et al. (Sept. 4 issue)(1) that were already mentioned in the accompanying editorial by Mattoo,(2) we note a potential confounding role of bacterial attachment factors on the reported results.(3) For example, uromodulin, the most abundant protein secreted in the urine of healthy persons,(4) organizes into filaments that competitively attach to Escherichia coli pili, thereby blocking the adhesion of the bacterial uroplakin to the urothelium and potentially decreasing the incidence of E. coli . . .
Morello, W., Puccio, G., Montini, G. (2024). Antibiotic Prophylaxis for Grade III, IV, or V Vesicoureteral Reflux in Infants. Reply. THE NEW ENGLAND JOURNAL OF MEDICINE, 390(6), 577-578 [10.1056/NEJMc2311879].
Antibiotic Prophylaxis for Grade III, IV, or V Vesicoureteral Reflux in Infants. Reply
Morello W.;
2024
Abstract
To the Editor: In addition to the limitations of the Antibiotic Prophylaxis and Renal Damage in Congenital Abnormalities of the Kidney and Urinary Tract (PREDICT) trial by Morello et al. (Sept. 4 issue)(1) that were already mentioned in the accompanying editorial by Mattoo,(2) we note a potential confounding role of bacterial attachment factors on the reported results.(3) For example, uromodulin, the most abundant protein secreted in the urine of healthy persons,(4) organizes into filaments that competitively attach to Escherichia coli pili, thereby blocking the adhesion of the bacterial uroplakin to the urothelium and potentially decreasing the incidence of E. coli . . .
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