Chronic postoperative pain (CPSP) is a major issue after surgery, which may impact on pa-tient’s quality of life. Traditionally, CPSP is believed to rely on maladaptive hyperalgesia and risk factors have been identified that predispose to CPSP, including acute postoperative pain. Despite new models of prediction are emerging, acute pain is still a modifiable factor that can be challenged with perioperative analgesic strategies. In this review we present the issue of CPSP, focusing on molecular mechanism underlying the development of acute and chronic hyperalgesia. Also, we focus on how perioperative strategies can impact directly or indirectly (by reducing postoperative pain intensity) on the development of CPSP.

Cazzaniga, S., Real, G., Finazzi, S., Lorini, F., Forget, P., Bugada, D. (2024). How to Modulate Peripheral and Central Nervous System to Treat Acute Postoperative Pain and Prevent Pain Persistence. CURRENT NEUROPHARMACOLOGY, 22(1), 23-37 [10.2174/1570159X21666230810103508].

How to Modulate Peripheral and Central Nervous System to Treat Acute Postoperative Pain and Prevent Pain Persistence

Lorini F;
2024

Abstract

Chronic postoperative pain (CPSP) is a major issue after surgery, which may impact on pa-tient’s quality of life. Traditionally, CPSP is believed to rely on maladaptive hyperalgesia and risk factors have been identified that predispose to CPSP, including acute postoperative pain. Despite new models of prediction are emerging, acute pain is still a modifiable factor that can be challenged with perioperative analgesic strategies. In this review we present the issue of CPSP, focusing on molecular mechanism underlying the development of acute and chronic hyperalgesia. Also, we focus on how perioperative strategies can impact directly or indirectly (by reducing postoperative pain intensity) on the development of CPSP.
Articolo in rivista - Articolo scientifico
adjuvants; Chronic postoperative pain; hyperalgesia; opioid free anes-thesia; persistent pain; postoperative pain; regional anesthesia;
English
15-ago-2023
2024
22
1
23
37
reserved
Cazzaniga, S., Real, G., Finazzi, S., Lorini, F., Forget, P., Bugada, D. (2024). How to Modulate Peripheral and Central Nervous System to Treat Acute Postoperative Pain and Prevent Pain Persistence. CURRENT NEUROPHARMACOLOGY, 22(1), 23-37 [10.2174/1570159X21666230810103508].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/524340
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