Idiopathic progressive chorea: misnomer or still reality? A case with neuropathological disconfirmation

A 50-year-old Caucasian woman was referred for marked and progressive generalized chorea. We searched for most of known causes of chorea with negative results. We were surprised since clinical practice and literature teach us that choreas without a detectable cause are doomed to progressively disappear with the advent of novel techniques and hypotheses, as for the concept of senile chorea. In contrast, our case takes us back exactly where we started from, clearly pointing out the need for still including uncertainty in our diagnostic algorithms for choreas.