Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease and diagnosis is mainly clinical and radiological. Correlation between radiographic data and clinical status has been reported. However, very few studies, especially in Caucasian people, describe the association between the Kellgren and Lawrence OA grading scale (KL) and genetic alterations to better understand OA etiopathogenesis and susceptibility. In order to update the knee OA grading, in this study we assessed the associations between KL grade, clinical features such as American Knee Society Score (AKSS), age, and polymorphisms in the principal osteoarthritis susceptibility (OS) genes in Sicilian individuals.

Minafra, L., Bravatà, V., Saporito, M., Cammarata, F., Forte, G., Caldarella, S., et al. (2014). Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. ARTHRITIS RESEARCH & THERAPY, 16(2) [10.1186/ar4535].

Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility

GILARDI, MARIA CARLA;MESSA, MARIA CRISTINA;
2014

Abstract

Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease and diagnosis is mainly clinical and radiological. Correlation between radiographic data and clinical status has been reported. However, very few studies, especially in Caucasian people, describe the association between the Kellgren and Lawrence OA grading scale (KL) and genetic alterations to better understand OA etiopathogenesis and susceptibility. In order to update the knee OA grading, in this study we assessed the associations between KL grade, clinical features such as American Knee Society Score (AKSS), age, and polymorphisms in the principal osteoarthritis susceptibility (OS) genes in Sicilian individuals.
Articolo in rivista - Articolo scientifico
Radiographic
English
2014
16
2
R91
none
Minafra, L., Bravatà, V., Saporito, M., Cammarata, F., Forte, G., Caldarella, S., et al. (2014). Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. ARTHRITIS RESEARCH & THERAPY, 16(2) [10.1186/ar4535].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/52335
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