IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishA 35-year-old woman with recurrent severe placenta-mediated pregnancy complications in her 2 pregnancies asks: Will low-molecular-weight heparin help prevent recurrent placenta-mediated pregnancy complications in my next pregnancy? We performed a meta-analysis of randomized controlled trials (RCTs) comparing low-molecular-weight heparin (LMWH) vs no LMWH for the prevention of recurrent placenta-mediated pregnancy complications. We identified six RCTs that included a total of 848 pregnant women with prior placenta-mediated pregnancy complications. The primary outcome was a composite of pre-eclampsia (PE), birth of a small-for-gestational-age (SGA) newborn (<10th percentile), placental abruption, or pregnancy loss >20 weeks. Overall, 67 (18.7%) of 358 of women being given prophylactic LMWH had recurrent severe placenta-mediated pregnancy complications compared with 127 (42.9%) of 296 women with no LMWH (relative risk reduction, 0.52; 95% CI, 0.32 to 0.86; P = .01; I-2, 69%, indicating moderate heterogeneity). We identified similar relative risk reductions with LMWH for individual outcomes, including any PE, severe PE, SGA <10th percentile, SGA <5th percentile, preterm delivery <37 weeks, and preterm delivery <34 weeks with minimal heterogeneity. LMWH may be a promising therapy for recurrent, especially severe, placenta-mediated pregnancy complications, but further research is required
Rodger, M.A., Carrier, M., Le Gal, G., Martinelli, I., Perna, A., Rey, E., et al. (2014). Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. BLOOD, 123(6), 822-828 [10.1182/blood-2013-01-478958].
| Citazione: | Rodger, M.A., Carrier, M., Le Gal, G., Martinelli, I., Perna, A., Rey, E., et al. (2014). Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. BLOOD, 123(6), 822-828 [10.1182/blood-2013-01-478958]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications | |
| Autori: | Rodger, MA; Carrier, M; Le Gal, G; Martinelli, I; Perna, A; Rey, E; de Vries, JI; Gris, JC; Chauleur, C; Molinari, N; Mares; P; Fabbro-Peray, P; Quere, I; Lefrant, JY; Haddad, B; Dauzat, M; van Pampus, MG; Hague, WM; Bezemerand, PD; Joosten, JH; Ruggenenti, P; Cetin, I; Pardi, G; Vergani, P; Acaia, B; Facchinetti, F; Sala, G; Bozzo, M; Rampello, S; Marozio, L; Diadei, O; Gherardi, G; Carminati, S; Remuzzi, G; Mannucci, PM; Garneau, P; David, M; Gauthier, R; Leduc, L; Michon, N; Morin, F; Demers, C; Kahn, SR; Magee, LA | |
| Autori: | ||
| Data di pubblicazione: | 6-feb-2014 | |
| Lingua: | English | |
| Rivista: | BLOOD | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1182/blood-2013-01-478958 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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