Objectives: To compare the diagnostic accuracy of dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MR imaging in detecting deep myometrial invasion in endometrial cancer, using surgical-pathological staging as reference standard. Methods: After searching a wide range of electronic databases and screening titles/abstracts, we obtained full papers for potentially eligible studies and evaluated according to predefined inclusion criteria. Quality assessmentwas conducted by adapting the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) checklist. From each study, we extracted information on diagnostic performance of DW and DCE sequences. After exploring heterogeneity, we adopted a bivariate generalized linear mixedmodel to compare the effect of the two MR sequences jointly on sensitivity and specificity. Results: Nine studies (442 patients) were considered. Significant evidence of heterogeneity was found only for specificity, both in DW and DCE imaging (I 2 = 70.8% and 70.6%). Pooled sensitivity of DW and DCE was 0.86 and specificity did not significantly differ (p=0.16) between the two sequences (DW=0.86 and DCE=0.82). No difference was found between 3-T and 1.5-T MR. There was no evidence of publication bias. Conclusions: MR diagnostic accuracy in presurgical detection of deep myometrial infiltration in endometrial cancer is high. DCE and DW imaging do not differ in sensitivity and specificity. Key Points: • Myometrial invasion is the most important morphological prognostic feature of endometrial cancer • MR diagnostic accuracy in presurgical detection of deep myometrial infiltration is high • MR examination including T2 and DCE imaging is considered the reference standard • DWimaging has been increasingly employed with heterogeneous results • This meta-analysis shows that DCE and DW do not differ in diagnostic accuracy. © European Society of Radiology 2014.
Andreano, A., Rechichi, G., Rebora, P., Sironi, S., Valsecchi, M.G., & Galimberti, S. (2014). MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis. EUROPEAN RADIOLOGY, 24(6), 1327-1338 [10.1007/s00330-014-3139-4].
Citazione: | Andreano, A., Rechichi, G., Rebora, P., Sironi, S., Valsecchi, M.G., & Galimberti, S. (2014). MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis. EUROPEAN RADIOLOGY, 24(6), 1327-1338 [10.1007/s00330-014-3139-4]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis | |
Autori: | Andreano, A; Rechichi, G; Rebora, P; Sironi, S; Valsecchi, MG; Galimberti, S | |
Autori: | ||
Data di pubblicazione: | 2014 | |
Lingua: | English | |
Rivista: | EUROPEAN RADIOLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00330-014-3139-4 | |
Appare nelle tipologie: | 01 - Articolo su rivista |