Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND™ polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.

Panseri, S., Russo, L., Montesi, M., Taraballi, F., Cunha, C., Marcacci, M., et al. (2014). Bioactivity of surface tethered Osteogenic Growth Peptide motifs. MEDCHEMCOMM, 5(7), 899-903 [10.1039/c4md00112e].

Bioactivity of surface tethered Osteogenic Growth Peptide motifs

RUSSO, LAURA;TARABALLI, FRANCESCA;CIPOLLA, LAURA FRANCESCA
2014

Abstract

Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND™ polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.
Articolo in rivista - Articolo scientifico
Osteogenic Growth peptides, regenerative medicine
English
2014
5
7
899
903
none
Panseri, S., Russo, L., Montesi, M., Taraballi, F., Cunha, C., Marcacci, M., et al. (2014). Bioactivity of surface tethered Osteogenic Growth Peptide motifs. MEDCHEMCOMM, 5(7), 899-903 [10.1039/c4md00112e].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/51843
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