Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.

Sironi, M., Biasin, M., Forni, D., Cagliani, R., De Luca, M., Saulle, I., et al. (2012). Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection. AIDS, 26(11), 1443-1445 [10.1097/QAD.0b013e328354b3c2].

Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection

Sironi M;
2012

Abstract

Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
Articolo in rivista - Articolo scientifico
Disease Susceptibility; Exodeoxyribonucleases; Female; Genetic Variation; HIV Infections; Humans; Immunity, Innate; Male; Phosphoproteins; Polymorphism, Single Nucleotide; Virus Replication
English
2012
26
11
1443
1445
reserved
Sironi, M., Biasin, M., Forni, D., Cagliani, R., De Luca, M., Saulle, I., et al. (2012). Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection. AIDS, 26(11), 1443-1445 [10.1097/QAD.0b013e328354b3c2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/514925
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