Bortezomib is an anti-neoplastic drug acting against multiple myeloma but its use is associated with the onset of painful peripheral neuropathy. Tumor necrosis factor-α (TNFα) is associated with the development of neuropathic pain; several models have shown that the inactivation of TNFα leads to a reduction in pain stimuli perception. The aim of the present study was to analyze if the administration of an antibody against TNFα is able to prevent the development of bortezomib-induced neuropathic pain.

Chiorazzi, A., Canta, A., Meregalli, C., Carozzi, V., Sala, B., Oggioni, N., et al. (2013). Antibody Against Tumor Necrosis Factor-α Reduces Bortezomib-induced Allodynia in a Rat Model. ANTICANCER RESEARCH, 33(12), 5453-5459.

Antibody Against Tumor Necrosis Factor-α Reduces Bortezomib-induced Allodynia in a Rat Model

CHIORAZZI, ALESSIA;CANTA, ANNALISA ROSANNA;MEREGALLI, CRISTINA;CAROZZI, VALENTINA ALDA;SALA, BARBARA;OGGIONI, NORBERTO;CAVALETTI, GUIDO ANGELO
2013

Abstract

Bortezomib is an anti-neoplastic drug acting against multiple myeloma but its use is associated with the onset of painful peripheral neuropathy. Tumor necrosis factor-α (TNFα) is associated with the development of neuropathic pain; several models have shown that the inactivation of TNFα leads to a reduction in pain stimuli perception. The aim of the present study was to analyze if the administration of an antibody against TNFα is able to prevent the development of bortezomib-induced neuropathic pain.
Articolo in rivista - Articolo scientifico
anti-TNFα; Bortezomib-induced neuropathy; allodynia; tumor necrosis factor-α
English
2013
33
12
5453
5459
none
Chiorazzi, A., Canta, A., Meregalli, C., Carozzi, V., Sala, B., Oggioni, N., et al. (2013). Antibody Against Tumor Necrosis Factor-α Reduces Bortezomib-induced Allodynia in a Rat Model. ANTICANCER RESEARCH, 33(12), 5453-5459.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/51254
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